Therapy for Fungal Infections
نویسندگان
چکیده
منابع مشابه
Antifungal therapy in invasive fungal infections.
Early treatment of invasive fungal infections (IFIs) is essential for optimal clinical outcomes. Standard antifungal drugs (polyenes, azoles and echinocandins) are not predictably effective against emerging yeasts and filamentous fungi and may cause undesirable side effects. Species identification can guide antifungal selection for invasive candidiasis, but not less common moulds such as Scedos...
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The prolonged immune deficiency resulting from haematopoietic stem cell transplant and chemotherapy predisposes to a high risk of invasive fungal infections. Despite the recent advances in molecular diagnostic testing, early initiation of pre-emptive antifungal therapy and the use of combination pharmacotherapy, mortality from invasive mould infections remain high among recipients of allogeneic...
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The effectiveness of miconazole was evaluated in 37 documented fungal infections, 32 of which were major infections. All patients were receiving therapy for advanced malignancy, with 28 patients having acute leukemia. The overall cure rate was 41% and it was also 41% for major fungal infections. Nine of 22 patients with Candida albicans infections were cured, and 3 of 11 patients with Candida t...
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New strategies to treat antibiotic-resistant infections are urgently needed. We serendipitously discovered that stem cell conditioned media possessed broad antimicrobial properties. Biochemical, functional, and genetic assays confirmed that the antimicrobial effect was mediated by supra-physiological concentrations of transferrin. Human transferrin inhibited growth of gram-positive (Staphylococ...
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Selection of appropriate specimens for culture and microscopic examination is based on the results of clinical and radiographic examination and consideration of the most likely fungal pathogen that may cause such an infection. Specimens should be collected under aseptic conditions or after appropriate cleaning and decontamination of the collection site and rapidly transported to the clinical my...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 1994
ISSN: 0025-6196
DOI: 10.1016/s0025-6196(12)61381-0